|
KMID : 1007520090180010245
|
|
Food Science and Biotechnology
2009 Volume.18 No. 1 p.245 ~ p.248
|
|
|
Equol Modulates Induction of Hepatic CYP 1A1, 1B1, and AhR in Mice Treated with 7,12-Dimethylbenz(a)anthracene
|
|
Choi Eun-Jeong
Kim Gun-Hee
|
|
|
Abstract
|
|
|
|
Present study was investigated the hepatic effects of equol on the 7,12-dimethylbenz(a)anthracene (DMBA)-induced enzymatic activity and expression of CYP1Al and CYP1B1 in mice. Equol was administered orally at 5 and 25mg/kg BW for 4 weeks. Subsequently, mice pretreated with equol received DMBA intragastrically twice a week for 2 weeks.DMBA induced CYP1 activity as well as the expression of CYP1A1 and CYP1B1. Each of these effects was significantlyreduced by equol in dose-dependent manner (p<0.05). Equol also reduced the relative AhR mRNA expression, similar to itseffect on CYP1A1. These results suggest that equol modulates the CYP1A1 through a reduction of AhR expression in micetreated with DMBA.
|
|
|
KEYWORD
|
|
|
aryl hydrocarbon receptor (AhR), cytochrome P450 enzyme, 7, 12-dimethylbenz(a)anthracene (DMBA), equol, in vivo
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|